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Continuous cell lines derived from human cancers are the mostwidely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions offundamental importance to the relevanceof human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative oftumors at that site is naĆÆve and misleading.


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Lines from an Artistic Life is the first book to explore the drawings of eminent Indian artist K.M. Adimoolam, well known in India and internationally for his meticulous...


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The book details an insight in the pathological mechanisms of experimental malaria by comparing the patterns of cytokine responses in mice. The study is intended for...


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Offers comprehensive information on breast cancer, including facts about the disease, causes of the disease, and how successful breast cancer treatments are.


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With advances in knowledge and technology, the proportion of cancer patients who have been cured or survive with cancers is growing, but a certain proportion of patients will...


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This pocket book explains the significant and well-documented impact that PET/CT can have on the management of prostate cancer through the provision of high-quality evidence...


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